Lecture_12_Epistasis_2011

Lecture_12_Epistasis_2011 - Epistasis Penetrance...

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Epistasis, Penetrance Feb 9 th 2011
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Announcements 3 rd problem set online Friday.
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Review PEDIGREE ANALYSIS is useful for genetics in humans. AUTOSOMAL RECESSIVE alleles can display phenotype in progeny of unaffected parents and can appear to “skip” generations. AUTOSOMAL DOMINANT alleles display phenotype in progeny of affected parents and do not appear to “skip” generations.
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How do genes interact to produce a phenotype? Look at pairs of genes: dihybrid crosses Single pathways Convergent pathways Levels of a phenotype
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Dihybrid Cross A/a;B/b X A/a;B/b 9:3:3:1 Ratio What if the genes are in the same cellular pathway?
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Novel Phenotypes: Dihybrid in single trait
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Dihybrid Cross A/a;B/b X A/a;B/b 9:3:3:1 Ratio What if the genes A and B are in the same cellular pathway?
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Epistasis “stand upon” ble mutant shows the phenotype of one mutation but not the
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Epistasis NE GENE _ black pigment B __ color deposition brown pigment b b no color deposition ess a dominant B allele is present you can’t detect the notype of A or a. Therefore b is epistatic to A and a.
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A/A;B/B A/A;B/b A/a;B/B A/a;B/b A/A;B/b A/A;b/b A/a;B/b A/a;b/b A/a;B/B A/a;B/b a/a;B/B a/a;B/b A/a;B/b A/a;b/b a/a;B/b a/a;b/b
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Lecture_12_Epistasis_2011 - Epistasis Penetrance...

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