Chapter 21.pe - Chapter21 AntidepressantAgents

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Chapter 21 Antidepressant Agents
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Affective Disorders vs Depression Affective disorder A person’s mood goes far beyond the normal “ups  and downs” Depression Severe and long-lasting feelings of sadness beyond  the precipitating event
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Signs and Symptoms of Depression Low energy level Sleep disturbances Lack of appetite Limited libido Inability to perform activities of daily living Overwhelming feelings of sadness, despair,  hopelessness, and disorganization
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Biogenic Amine Theory of Depression Depression results from a deficiency of norepinephrine  (NE), dopamine, or serotonin (5HT) Monoamine oxidase (MAO) may break them down to  be recycled or restored in the neuron Rapid fire of neurons may lead to their depletion The number or sensitivity of postsynaptic receptors  may increase, depleting neurotransmitter levels
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Actions of Antidepressant Therapy Inhibits the effects of MAO, leading to increased NE or  5HT in the synaptic cleft Blocks reuptake by the releasing nerve, leading to  increased neurotransmitter levels in the synaptic cleft Regulates receptor sites and breakdown of  neurotransmitters, leading to an accumulation of  neurotransmitters in the synaptic cleft
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Classifications of Antidepressants
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Chapter 21.pe - Chapter21 AntidepressantAgents

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