Chapter 23.pe - Chapter23 AntiepilepticAgents &Wilkins...

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Chapter 23 Antiepileptic Agents 
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Factors Affecting the Type of Seizure Location of the cells that initiate the electrical  discharge Neural pathways that are stimulated by the initial  volley of electrical impulses
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Classification of Seizures Generalized seizures  Begin in one area of the brain and rapidly  spread throughout both hemispheres of the  brain Partial seizures or focal seizures Begin and remain in one area of the brain
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Classification of Generalized Seizures Tonic–clonic seizures (grand mal seizures) Absence seizures (petit mal seizures)  Myoclonic seizures  Febrile seizures  Status epilepticus
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Classification of Partial Seizures Simple partial seizures  Occur in a single area of the brain and may  involve a single muscle movement or sensory  alteration Complex partial seizures  Involve complex sensory changes  Motor changes may include involuntary urination,  chewing motions, diarrhea, etc.
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Drugs for Treating Tonic–Clonic Seizures Hydantoins Barbiturates Barbiturate-like drugs
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Sites of Action of Drugs Used to Treat Various  Forms of Epilepsy
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Hydantoins Phenytoin ( Dilantin ) Treats tonic–clonic seizures and status epilepticus;  prevents and treats seizures after neurosurgery Ethotoin ( Peganone Controls tonic–clonic and myoclonic seizures Fosphenytoin ( Cerebyx Controls short-term status epilepticus; prevents seizures  after neurosurgery Mephenytoin ( Mesantoin Treats tonic–clonic, myoclonic, and partial (focal) seizures  in patients who do not respond to less toxic antiepileptic  agents
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Hydantoins (cont.)
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This note was uploaded on 02/19/2011 for the course RNSG 1301 taught by Professor Loftin during the Spring '11 term at Lone Star College.

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Chapter 23.pe - Chapter23 AntiepilepticAgents &Wilkins...

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