Chapter 32.pe - Chapter32 CholinergicAgents &Wilkins...

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Chapter 32 Cholinergic Agents
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Cholinergic Drugs Definition Chemicals that act at the same site as the  neurotransmitter acetylcholine (ACh) Actions  Often called parasympathomimetic drugs because  their action mimics that of the PSNS Since they are not limited to a specific site,  cholinergics are associated with many undesirable  systemic effects
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Types of Cholinergic Agonists Direct-acting cholinergic agonists  Occupy receptor sites for ACh on the  membranes of the effector cells of the  postganglionic cholinergic nerves Cause increased stimulation of the  cholinergic receptor
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Types of Cholinergic Agonists (cont.) Indirect-acting cholinergic agonists  React with the enzyme acetylcholinesterase,  preventing it from breaking down the ACh that was  released from the nerve Cause increased stimulation of the ACh receptor  sites 
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Pharmacodynamics of Cholinergic Drugs
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Direct-Acting Cholinergic Agonists and Their  Indications Bethanechol ( Duvoid, Urecholine Treats urinary retention and neurogenic bladder  atony  Diagnoses and treats reflux esophagitis  Carbachol ( Miostat ) and pilocarpine ( Pilocar ) Induce miosis or pupil constriction Relieve intraocular pressure of glaucoma For use in certain surgical procedures
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Direct-Acting Cholinergic Agonists 
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This note was uploaded on 02/19/2011 for the course RNSG 1301 taught by Professor Loftin during the Spring '11 term at Lone Star College.

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Chapter 32.pe - Chapter32 CholinergicAgents &Wilkins...

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