Chapter 40.pe - Chapter40...

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Chapter 40 Drugs Affecting the Female Reproductive  System
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Sites of Action of Drugs Affecting the Female  Reproductive System
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Drugs Used to Affect the  Female Reproductive System Estrogen and progestins Estrogen receptor modulators Fertility drugs Oxytocics Abortifacients Oncolytics
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Estrogen Actions Protects the heart from atherosclerosis Retains calcium in the bones Maintains the secondary female sex  characteristics Indications Hormone replacement therapy (HRT) Palliative and preventive therapy during  menopause
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Estrogen (cont.) Pharmacokinetics Absorbed through the GI tract and undergoes  extensive hepatic metabolism Excreted in the urine Contraindications Allergies and pregnancy Idiopathic vaginal bleeding, breast cancer, estrogen- dependent cancer, and thromboembolic disorders
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Estrogen (cont.) Cautions Breast feeding, metabolic bone disease, renal  insufficiency, and hepatic impairment Adverse effects  GU tract Systemic effects of estrogens Drug-to-drug interactions Drugs that enhance hepatic metabolism Corticosteroids
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Sites of Action of the Estrogens
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Estrogen Receptor Modulators Actions Modulating effects on estrogen receptors Used to stimulate specific estrogen  receptors to increase bone mineral  density Indication
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Estrogen Receptor Modulators (cont.)
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Chapter 40.pe - Chapter40...

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