Chapter 47.pe - Chapter47 LipidLoweringAgents

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Chapter 47 Lipid-Lowering Agents
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Action of Antihyperlipidemic Agents Lower serum levels of cholesterol and lipids Prevention of CAD
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Unmodifiable Risk Factors for CAD Genetic predisposition Age  Gender
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Modifiable Risk Factors for CAD Gout Cigarette smoking Sedentary lifestyle High stress levels Hypertension Obesity Diabetes  Untreated bacterial infections  Treatment with tetracycline and  fluororoentgenography
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Metabolism of Fats in the Body
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Lipoproteins Produced in the Liver Low-density lipoproteins (LDL)  Enter circulation as tightly packed cholesterol,  triglycerides, and lipids Carried by proteins that enter circulation; broken  down for energy or stored for future use as energy High-density lipoproteins (HDL) Enter circulation as loosely packed lipids  Used for energy; pick up remnants of fats and  cholesterol left in the periphery by LDL breakdown
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Cellular Production of Cholesterol
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Causes of Hyperlipidemia Excessive dietary intake of fats  Genetic alterations in fat metabolism leading to a  variety of elevated fats in the blood  Hypercholesterolemia, hypertriglyceridemia, and  alterations in LDL and HDL concentrations
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Lipid Blood Level Classification
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Chapter 47.pe - Chapter47 LipidLoweringAgents

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