Chapter 48.pe - Chapter48 DrugsAffectingBloodCoagulation

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Chapter 48 Drugs Affecting Blood Coagulation
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Process of Coagulation
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Blood Vessel Injury Local vasoconstriction seals off small injury  Platelet aggregation forms a platelet plug Hageman factor is activated Intrinsic pathway converts prothrombin to  thrombin to seal system Extrinsic pathway clots the blood that has leaked  out of the vascular system
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Damaged Vessel Endothelium Stimulates   Platelets to Cause Platelet Adhesion
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Types of Blood Disorders Thromboembolic disorder Conditions that predispose a person to the  formation of clots and emboli   Hemorrhagic disorder Condition in which excess bleeding occurs
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Actions of Anticoagulants Anticoagulants  Interfere with the clotting cascade and thrombin  formation  Antiplatelets Alter the formation of the platelet plug  Thrombolytic drugs  Break down the thrombus that has been formed by  stimulating the plasmin system  
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Antiplatelets Action Inhibit platelet adhesion and aggregation by blocking  receptors sites on the platelet membrane Anagrelide: blocks the production of platelets in the bone  marrow Indications Reduce risk of recurrent TIAs or strokes; reduces death or  nonfatal MI; MI prophylaxis; anti-inflammatory, analgesic,  and antipyretic effects Pharmacokinetics Well absorbed and bound to plasma proteins Metabolized in the liver and excreted in the urine
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Antiplatelets (cont.) Contraindications Allergy, pregnancy, and lactation Caution Bleeding disorder, recent surgery, closed head injury Adverse effects  Bleeding Headache, dizziness, and weakness GI distress Drug-to-drug interaction Other blood-clotting drugs
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Anticoagulants and Their Indications
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Chapter 48.pe - Chapter48 DrugsAffectingBloodCoagulation

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