Chapter 51.pe - Chapter51 DiureticAgents

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Chapter 51 Diuretic Agents
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Classes of Diuretics Thiazide and thiazide-like diuretics Loop diuretics Carbonic anhydrase inhibitors Potassium-sparing diuretics Osmotic diuretics
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Function of Diuretic Agents Increase the amount of urine produced by the  kidneys Increase sodium excretion
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Indications for Diuretic Use Edema associated with congestive heart failure Acute pulmonary edema Liver disease (including cirrhosis) Renal disease Hypertension Conditions that cause hyperkalemia
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Site of Action of Diuretics 
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Thiazide and Thiazide-Like Diuretics Hydrochlorothiazide ( HydroDIURIL Chlorothiazide ( Diuril ) Bendroflumethiazide ( Naturetin ) Benzthiazide ( Exna ) Hydroflumethiazide ( Diucardin ) Methyclothiazide ( Aquatensen ) Polythiazide ( Renese ) Trichlormethiazide ( Diurese
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Thiazide and Thiazide-Like Diuretics (cont.) Actions Block the chloride pump Keep the chloride and sodium in the tubule to be  excreted in the urine, thus preventing the  reabsorption of both in the vascular system Indications Treatment of edema associated with CHF and liver  or renal disease Monotherapy or adjuncts for the treatment of  hypertension
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Thiazide and Thiazide-like Diuretics (cont.) Pharmacokinetics Well absorbed from the GI tract, metabolized in the liver,  and excreted in the urine Contraindications Allergy to thiazides and sulfonamides Fluid and electrolyte imbalances and renal or liver disease Cautions
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Chapter 51.pe - Chapter51 DiureticAgents

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