Chapter 52.pe - Chapter52 DrugsAffectingthe...

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Chapter 52 Drugs Affecting the  Urinary Tract and the Bladder
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Urinary Tract Infections Second most common infection in the US More common in females Patients with indwelling catheters or intermittent  catheterization are at risk
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Signs and Symptoms of a UTI Urinary frequency Urgency Burning on urination (associated with cystitis) Chills, fever, flank pain, and tenderness (associated  with acute pyelonephritis)
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Treatment for UTIs Antibiotics  Specific agents to sterilize the urinary tract Drugs that:  Block spasms of the urinary tract muscles Decrease urinary tract pain Protect the cells of the bladder from irritation Treat enlargement of the prostate gland in men
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Sites of Action of Drugs  Acting on the Urinary Tract
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Antibiotic Anti-infectives Cinoxacin ( Cinobac ): interferes with DNA replication in gram- negative bacteria Norfloxacin ( Noroxin ): effective against even more gram- negative strains than cinoxacin Fosfomycin ( Monurol ): offers convenience of once only dosing Nalidixic acid ( NegGram ): older drug, not effective against as  many strains of gram-negative bacteria  Nitrofurantoin ( Furadantin ): older drug with a very short half- life
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UTI Anti-infectives That Acidify the Urine Methenamine ( Hiprex Undergoes metabolism in the liver and is excreted in  the urine Provides established dosage guidelines for children  and comes in a suspension form Methylene blue ( Urolene Blue Widely distributed, metabolized in the tissues, and  excreted in the urine, bile, and feces
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Anti-infectives
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Chapter 52.pe - Chapter52 DrugsAffectingthe...

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