Chapter 54.pe - Chapter54 DrugsActingonthe...

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Chapter 54 Drugs Acting on the  Upper Respiratory Tract
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Drugs That Affect the Respiratory System Antitussives Block the cough reflex Decongestants Decrease the blood flow to the upper respiratory tract  and decrease the overproduction of secretions Antihistamines Block the release or action of histamine, which  increases secretions and narrows airways
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Drugs That Affect the Respiratory System (cont.) Expectorants Increase productive cough to clear airways Mucolytics Increase or liquefy respiratory secretions to aid  clearing of airways
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Sites of Action of Drugs Working on the  Respiratory System
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Antitussives Action Act directly on the medullary cough center of the brain to  depress the cough reflex Indication Control nonproductive cough Pharmacokinetics Rapidly absorbed, metabolized in the liver, and excreted  in the urine Contraindications Patients who need to cough to maintain the airway Head injury and impaired CNS
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Antitussives (cont.) Caution Hypersensitivity or history of narcotic addiction  Adverse effects  Drying effect on the mucous membranes  CNS effects: drowsiness and sedation GI upset
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Topical Nasal Decongestants Actions Sympathomimetic Affect sympathetic nervous system to cause vasodilation Cause less inflammation of the nasal membrane Indications Relieve the discomfort of nasal congestion that  accompanies the common cold, sinusitis, and allergic  rhinitis
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Topical Nasal Decongestants (cont.)
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This note was uploaded on 02/19/2011 for the course RNSG 1301 taught by Professor Loftin during the Spring '11 term at Lone Star College.

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Chapter 54.pe - Chapter54 DrugsActingonthe...

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