Chapter 57.pe - Chapter57...

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Chapter 57 Drugs Affecting Gastrointestinal Secretions
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Underlying Causes of GI Disorders Dietary excess Stress Hiatal hernia Esophageal reflux Adverse drug effects  Peptic ulcer disease
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Effect of Drugs on GI Secretions Decrease GI secretory activity Block the action of GI secretions Form protective coverings on the GI lining to prevent  erosion from GI secretions Replace missing GI enzymes that the GI tract or ancillary  glands and organs can no longer produce
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Peptic Ulcers Definition Erosions in the lining of the stomach and adjacent areas  of the GI tract Symptoms Gnawing, burning pain that often occurs after meals  Cause Bacterial infection by  Helicobacter pylori  bacteria  
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Drugs Used in the Treatment of Ulcers Histamine-2 (H 2 ) antagonists Block the release of hydrochloric acid in  response to gastrin Antacids Interact with acids at the chemical level to  neutralize them Proton pump inhibitors Suppress the secretion of hydrochloric acid into  the lumen of the stomach
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Drugs Used in the Treatment of Ulcers (cont.) Antipeptic agents Coat any injured area in the stomach to prevent further  injury from acid Prostaglandins Inhibit the secretion of gastrin and increase the  secretion of the mucous lining of the stomach,  providing a buffer
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Sites of Actions of Drugs Affecting  Gastrointestinal Secretions
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Histamine-2 (H 2 ) Antagonists Action Selectively block histamine-2 receptor sites, leading  to a reduction in gastric acid secretion and reduction  in overall pepsin production Indications Short-term treatment of active duodenal ulcer or  benign gastric ulcer  Treatment of pathological hypersecretory conditions  such as Zollinger–Ellison syndrome
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Histamine-2 (H
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This note was uploaded on 02/19/2011 for the course RNSG 1301 taught by Professor Loftin during the Spring '11 term at Lone Star College.

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Chapter 57.pe - Chapter57...

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