Chapter 58.pe - Chapter58 LaxativeandAntidiarrhealAgents

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Chapter 58 Laxative and Antidiarrheal Agents
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Actions of Drugs Used to Affect  Motor Activity of the GI Tract Speed up or improve movement of intestinal contents  when it becomes slow or sluggish (constipation)  Increase the tone of the GI tract and stimulate motility  throughout the system Decrease movement along the GI tract when rapid  movement decreases the time for absorption of  nutrients (diarrhea)
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Site of Action of Drugs Affecting  GI Motility
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Types of Laxatives Chemical stimulants Chemically irritate the lining of the GI tract Bulk stimulants   Cause the fecal matter to increase in bulk Lubricants Help the intestinal contents move more smoothly
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Types of Chemical Stimulants Cascara ( generic ): reliable agent that leads to intestinal  evacuation Senna ( Senokot ): reliable drug, similar to cascara in  action (OTC) Castor oil ( Neoloid ): old standby for thorough evacuation  of the intestine Bisacodyl ( Dulcolax ): very popular OTC laxative that has  been withdrawn from the market  
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Types of Bulk Stimulants Magnesium sulfate ( Epsom   Salts ) Magnesium citrate ( Citrate of Magnesia Magnesium hydroxide ( Milk of Magnesia Lactulose ( Chronulac Polycarbophil ( FiberCon Psyllium ( Metamucil )
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Types of Lubricating Laxatives
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Chapter 58.pe - Chapter58 LaxativeandAntidiarrhealAgents

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