11. signalling pathway

11. signalling pathway - regulate the transcription of...

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Chemical signal and receptor Cascade Amplificati on step(s) Down regulation Example Steroid hormone signalling pathway Target DNA Steroids are hydrophobic and lipid soluble diffuse freely through the membrane Bind with specific steroid receptor in the cytosol. Binding cause the swinging of the hinge region release the inhibitory protein complex DNA binding domain exposed Steroid-receptor complex enters the nucleus Act as transcription factor
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Unformatted text preview: regulate the transcription of primary response gene A Gene A translation produces A which regulates secondary gene B and C One molecule of hormone produces many molecules of protein A Block DNA binding site Complex gets transported out of the nucleus Disadvanta ge: Lon g term develop ment pathway only because of the delay in translati on (protein producti on) Dow...
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11. signalling pathway - regulate the transcription of...

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