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pKa handout - pita calculations 1 A lysine ls near an...

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Unformatted text preview: pita calculations 1. A lysine ls near an aspartic acid in the protein sequenoe. til-she's aroltle has a pita of 1M under normal oondltioos and aspartic aclcl has I pita of 3.5 under normal conclltlons. Thls question wlll examine how it changes. a. what is the mtg; ah the probona‘lied form of luslne? The demote-hated tat-m? @JGD b. What is the charge clothe pr-ortonated form of aspartic acid?The deprotonated tori-n? fig) c. Assume for I moment that the pita“: won‘t change drastlclihr. Whlchof the two residues are protonated at each ofthe following oH*s l“tote: it can be neither; one or both}? ”Eli I. pH 1 13...“. Wnfi‘a Ffl 011.. ”Etta-i lil. PH? L‘G‘ -eih‘tbhe-+d_~, a,“ -Ae-proitunniei 5 in. pH 13 we math-mite [H cl. At pH 3". aspartic acld adapts either a protonated or deprotonateo fem {see answer to cl. Which of the taro forms of lysine [protenated or depretonatedl Is stabllioecl In- this form? How does the pita change? flfi““dtas—-Wokmdma C:i “mewflmmhdiknn a edahnt hat-*hw J_i:) 3 Ht'9hfifigi atiee madam e. Repeat the problem but replaoe asoartie aciol with another Mine. Now which form of F“ lysine is stabilized at pH: Tr‘ H-o‘titI oloes the pull: chance? Requiem-filial 9m, betzmce El (lat-3:4 “FE-5* /Lpt:.tamh tea-akin. ‘th 1m,- mflaem. 2. The on of all atoms is given below. Clothe graph plotthe charge of the molecule at the following pH's increroEnting up he 1 the. at 1 2, 3, ill 5. -. lat] :3 IflIIIIIIIIIII IIIEIIIIIIIII HIlla-lanolin that f: llllllllle Ill -1 IIIIIIIIIIEII —3 IIIIIIIIIIIII Iafii‘illil _. n-rH pH liiagah What Is the pl ofthe following peptfle shown as it would appear at pH 't'? PI=lD ...
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