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img008 - materials There are five major w of leukocytes...

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Unformatted text preview: materials. There are five major w of leukocytes, each with a particular role in immunityfleamophfls engulf microorganisms, abnormal cells, and foreign particles by phagocytosis. Eosinophil — secrete enzymes that kill parasites; contribute to tissue damage in allergic reactions; Basophil — secretes chemical mediators of inflammation and allergic reactions; Wes —- secrete cytokines; engulf microorganisms by phagocytosis. Manocytes migrate into tissues where they become macrophages (big eaters); L h tes — play various roles in the immune system. Click the Home Menu Button WWWW‘M‘W'MW “mm Click the Platelets and hemostasis Button: Blood , Blood mm: on W immunity. loading to Int-ml vessels get damaged frequently, lending to internal and/or [K audio: ext-mu blood "g external bleeding. Without some mechanism to stop bleeding even a superficial cut would cause death due to blood loss. bin-d hop g::" m d M, m. _ G0 to the next screen: When a blood vessel is damaged, McMillan to m' i intrinsic mechanisms trigger a constriction called vascular m m 3 spasm which increases resistance to blood flow. Damage also cutmuld com a 9 tends to activate the sympathetic nervous system, which , "M" ‘° W '° W causes further vasoeonsmction. This minimizes blood loss‘ ' other mechanisms also play a role to stop the loss of blood altogether. ’ 1 ‘ V ' 33:15 “ALA” “(A RX} Lia vs a m” "h“ ' ' " "mm" Go to the next screen: film, also called "~me (WHEL, mm a " throm es, are non-nucleated fragments of M m H w ”I w. Platelets possess granules containing a and. Rim 1.. an. ”'23,... Wigm variety of substances that can be secreted into plasma, W— "m“ _, . including ADP, serotonin, epinephrine, and a variety of Em... / "define” "W“ ' ‘ l chemicals that participate in the formation of a blood clot. m grmuznmoz'nwn M M m Platelets are also sticky under certain conditions, allowing warm!” on mufi—myf them to adhere to surfaces, especially those of damaged 67' 9‘ blood vessels. g (I -\‘ ..... I Vet Go to the next screen: Both the formation of the platelet plugs and the subsequent blood ciot require the Eti 0 presence of platelets and a fairly large set of specific plasma proteins. The first step in plgsgnaflugiomlation is platelgt adhesion. which occurs when bIOOdJfifil 9911133“ exmses tissue underlying the endothelium. A key protein released is von Willebrand factor thO that accumulates at the site of vessel damage. m‘mw MM Go to the next screen: When blood contacts this W Wm M - mu M m "- subendothelial tissue VW in the “m "W “W P“ subendothelium, triggering the WW ”PM" WW MW” which WW. Contact with va also w—u—u . . activates plateletsz changing their metabolism and surface a..— properties makingjhemsficky. G0 to the next screen: The production of thromboxane A2 (TXAZ) further supports platelet ggregation. - 2 ‘ formed from a pho ' ' hidonic W in the m latelets. ’l'XAz has many roles in homeostasis, including stimulation of platelet aggregation providing positive feedback for platelet plug formation and vasoconstriction. Platelet formation is limited to the area of Dun-A < AFR t “\L 6’“ 96’6“ ...
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