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Unformatted text preview: 601m I‘m hem—em Tram-racemes: Manhattan-I “WWW momma- Mbbodlalllnd WWW tobmlclrbontcudd “limb m by catholic anhydrase 0 institution“ Tam-W mentally. Mot-blon- mmumm Hoodoo.“ mm“ in. Dunn 7 nf‘ Go to the next screen: And the rest will dissolve in the plasma as bicarbonate ions Go to the next screen: Now we are at the lungs. The lungs have a low pCOz and the carbarninohemoglobin dissociates. Go to the next screen: The CO; diffiises into the alveolus. Go to the next screen: Now let’s go back to the tissues and take a look how bicarbonate ions are formed. Click How does this happen see more: Bicarbonate is formed from carbon dioxide within erythrocytes in systemic capillaries, where carbon dioxide levels are highest Erythrocytes are able to form bicarbonate because they contain the enzyme carbonic anhydrase. Go to the next screen: Carbonic anhydiase catalyzes the reversible reaction that converts carbon dioxide and water to carbonic acid (H2C03). Go to the next screen: The pathway continues with the reversible dissociation of carbonic acid, which yields a hydrogen ion and a bicarbonate ion. This reaction follows the law of mass action meaning that an m in carbon dioxide concentration drives the reaction to the right, producing more hydrogen ions and bicarbonate ions. Axlecrase in C02 forces the equation WK bicarbonate ions were allowed to accumulate in erythrocytes the reaction of carbon dioxide with water would slow down and eventually come to equilibrium. To prevent this fi’om happening bicarbonate and hydrogen ions must be removed from the erythrocytes. ...
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