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img031 - Click the see close-up of Cl-HCO3 exchanger button...

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Unformatted text preview: Click the see close-up of Cl-HCO3 exchanger button: Bicarbonate ions are transported into the plasma in exchange for a chloride ion via a transport protein in the erythrocyte plasma membrane. The coupled movement of chloride ions into the erythrocyte and bicarbonate into the plasma is called the chloride shifi. Click the Back Button: Many of the hydrogen ions produced by the reaction are buffered by binding to hemoglobin. G0 to the next screen: Within the plasma bicarbonate is important in acid-base balance because an increase in PC02 causes an increase in the acidity of the blood (the concentration of H ions increases), and a decrease in PC02 causes a decrease in the acidity of the blood. MM" W". Go to the next screen: Now we are back at the , lungs. Here we will take a look at how bicarbonate lathe lungs, co. releases the C02. The C02 that is dissolved in mafim plasma diffuses into the alveoli. This lowers the m W "m“ P002 of the blood causing the chemical reactions we just diswssed to reverse. TN! b"! Chi P001 in the floor! will rm W Go to the next screen: Bicarbonate is transported back into the erythrocyte via the same chloride — HCO; transporter. Bicarbonate spontaneously combines with hydrogen ions to form 8 carbonic acid. Go to the next screen: Carbonic anhydrase catalyzes carbonic acid into C02 and water. Go to the next screen: 'Ihe CD; then diffuses into the plasma and then into the alveoli. Click the back button mm' * MMMOWM “:1"le Go to the next screen: Note some C02 does W m combine with hemoglobin and some remains W *Cammm-nmmnmomum . . . “m dissolved in plasma. However, most Will be 2"“ *mm’“'°""“"‘°"°°"""°“‘ convertedtzobicarbonateJustasthePCOz ofthe a... blood is one of the many factors that affect the an“ affinity of hemoglobin for oxygen, and thus the 3:; oxygen carrying capacity of blood, the P0: of blood at... also afl‘ects the affinity of hemoglobin for carbon ~— dioxide, and the bloods ability to transport carbon dioxide. Total blood carbon dioxide rises with increasing P002. The carbon dioxide content of the EE_ blood falls as the P02 rises — this phenomenon is known as the Haldane effect. One reason for the Haldane effect is that binding oxygen to hemoglobin decreases the affinity of hemoglobin for carbon dioxide. Therefore, when P02 increases, the amount of carbon dioxide that can be transported bound to hemoglobin decreases because hemoglobin is carrying more oxygen. Conversely, a decrease in P0; promotes the binding of carbon dioxide to hemoglobin. Dunn '1 AF‘ ...
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