img053 - SA Node Cell Na Cai" l l ‘ I “I'M-a6 v...

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Unformatted text preview: SA Node Cell Na+ Cai"\ l l ‘ I “I'M-a6 v o'— Twain—indoo- n ' all-[- "I Wmmmafi SA Node Cell ‘ Na+ Mum-ant! ' .- 0"“ mmmw-umm but "in“ WWW mac-Hula mimic-lit SA Node CI“ .......... mum-00V ' 0"" mmnmd—mommmm—n m... afim Page 5 of8 Go to the next screen: “this initial depolarization opens voltage gated calcium channels called T—type (transient) channels. This raises the Pea, which depolarizes the cell further. G0 to the next screen: The T~type channels stay open for a short period of time before inactivating. Go to the next screen: The T—type calcium channels trigger the opening of L-type (long lasting) calcium channels that stay open longer and close slowly. The result is a large increase in Ca-H- into the cell, which produces rapid depolarization characteristic of the upswing of the action potential. At peak depolarization potassium channels are stimulated to begin opening. Go to the next screen: The opening ofpotassium channels acts to pull the membrane potential back down. Pumps are transporting Ca++ back into the extracellular space during repolan'zation. As well the Na/K pumps work to pump sodium out and potassium in once the membrane potential reaches resting potential. The process repeats. You can replay the steps again by clicking the Repeat Button ...
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