ETC and TCA 2010 with markups_1

ETC and TCA 2010 with markups_1 - NTR 500 Energy and...

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Click to edit Master subtitle style NTR 500 Fall 2003 NTR 500 Fall 2003 11 NTR 500 Energy and Protein Nutrition Energy Nutrition Oxidative Phosphorylation TCA Cycle and Electron Transport Chain
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NTR 500 Fall 2003 NTR 500 Fall 2003 22 A. Oxidative Phosphorylation 1. Names a. Electron Transport Chain b. Oxidative Phosphorylation c. Cellular Respiration (O2 to CO2) 2. Function a. ATP generation NOT Substrate Phosphorylation (that is found in glycolysis and TCA) b. Oxidized coenzymes generation (FAD+ and NAD+) from reduced FADH2 and NADH FAD (riboflavin) NAD (niacin) 3. Location a. Mitochondria small fraction of mitochondria enzymes from mtDNA degrades with age (10-20x higher mutation rate than nuclear DNA) Maternal origination apoptosis by internal pathway through capsases Caused by radiation, drugs, removal of cytokines and genetic damage (cell stress)
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NTR 500 Fall 2003 NTR 500 Fall 2003 33 Crow MT,Mani K,Nam YJ,Kitsis RN. The mitochondrial death pathway and car myocyte apoptosis. Circ Res. 2004 Nov 12;95(10):957-70. Haupt S,Berger M,Goldberg Z,Haupt Y. Apoptosis - the p53 network. J Cell Sci. 2003 Oct 15;116(Pt 20):4077-85. Review Don’t learn, just for your info
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NTR 500 Fall 2003 NTR 500 Fall 2003 44 b. Outer membrane 1) Varied shape 2) Permeable to most ions and small compounds (Mwt < 500) 3) Transporters Porins (Pyruvate, FFA) c. Inner membrane 1) Impermeable (esp. H+) 2) Special transporters 3) Cristae (folds) 4) Electron Transport and Oxidative Phosphorylation enzymes 5) ATP synthase complexes
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NTR 500 Fall 2003 NTR 500 Fall 2003 55 d. Matrix (about 80 proteins – ¾ from the mitochondria) 1) Energy substrate oxidation (CHO, Amino Acids, β-Oxidation) (not drug metabolism) 2) TCA cycle 3) Urea synthesis (liver) 4) Steroid synthesis (rate limiting)
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NTR 500 Fall 2003 NTR 500 Fall 2003 66 4. Electron Transport Chain oxidize reduced substrates use energy to pump H+ out a. Five Complexes and CoQ 1) Complex I iron NADH to FMNH2 ( NADH dehydrogenase ) CoQH2 and some superoxide superoxide leakage CoQ - HMGCoA reductase reduced with age and with Statin drugs NADH (glycolysis) produced outside from reduced substrates being oxidized and shuttled in Internal matrix (B-oxidation and TCA) 1) Complex II Reduced substrate oxidized Succinate FADH2 produced ( dehydrogenases ) CoQH2 TCA
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NTR 500 Fall 2003 NTR 500 Fall 2003 77 3) CoQ (with FMNH2 and FADH2 ) to reduced CoQH2 4) Complex III and IV (Iron)
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This note was uploaded on 02/21/2011 for the course NTR 503 taught by Professor Dr.lisa during the Spring '10 term at SUNY Buffalo.

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ETC and TCA 2010 with markups_1 - NTR 500 Energy and...

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