ETC TCA Review

ETC TCA Review - 3. Regulation a. ATP inhibits Complex 3...

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Click to edit Master subtitle style 11 NTR 500 Energy and Protein Nutrition Energy Nutrition Review
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22 A. Oxidative Phosphorylation (ETC) 1. Overview a. Occurs in mitochondria 1) Outer membrane –permeable 2) Inner Membrane i. impermeable (esp. protons) ii. Transporters, ETC enzymes, ATP synthetics 3) Matrix – TCA, etc b. Consumption of NADH and FADH2 (reduced) 1) From TCA and glycolysis 2) With generation of NAD + and FAD (oxidized) 3) Intermediate production of reduced cofactors i. FMNH2, CoQH2 and c. Consumption of Oxygen d. Production of ATP 1) Oxidative Phosphorylation (not substrate phosphorylation)
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33 2. ETC reactions a. Complex 1 1) NADH (from outside MT) oxidized 2) by NADH dehydrogenate 3) FMNH2 produced 4) Proton pumped out b. Complex 2 1) Succinate oxidized 2) FADH2 produced c. Complex 3 and 4 1) CoQ to CoQH2 from FADH2 or FMNH2 2) Proton pumped out 3) O2 consumed (H20 produced) d. Complex 5 (ATP synthetase) 1) ATP from proton and electrical gradient (Chemiosmotic)
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Unformatted text preview: 3. Regulation a. ATP inhibits Complex 3 & 4 (T3 inhibits this – BMR inc) b. ADP stimulates ATP synthetase c. Lack of substrates reduce activity (02, NADH, etc) 4. Uncoupling Protein - Brown fat, heat, norepinephrine 44 B. TCA cycle 1. Overview a. NADH and FADH2 produced (most of ATP production, some GTP) b. Production of (anaplerosis) 1) PEP (for gluconeogenesis) 2) Aspartate & Glutamate c. Consumption of 1) Pyruvate and Acetyl CoA i. Citrate formed with Oxaloacetate (rate limiting) used ii. Inhibited by APP, NADH, etc. 2) C4/C5 intermediates (cataplerosis) 55 2. Reactions a. Dehydrogenase 1. NADH or FADH2 and CO2 formed 2. In general inhibited by ATP and NADH b. Succinate thiokinase 1) GTP by substrate phosphorylation c. Malate Oxidation 1) NADH and Oxaloacetate produced...
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This note was uploaded on 02/21/2011 for the course NTR 503 taught by Professor Dr.lisa during the Spring '10 term at SUNY Buffalo.

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ETC TCA Review - 3. Regulation a. ATP inhibits Complex 3...

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