NTR 503 - Wilson Lecture 4 - Nov 4 2010 - students' version

NTR 503 - Wilson Lecture 4 - Nov 4 2010 - students' version...

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1 Fe fractional absorption by intestine is 5-40% (pp 537-9) Transferrin transports Fe in plasma Mucosal block: when transferrin saturated, enterocytes store ferritin-Fe until they slough off When Fe stores low, less ferritin is synthesized
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2 Figure 12.1 Fig 15-2 (again)
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3 Iron Needs (p 537) RDA (assumes 18% fractional absorption) Males: 11 mg/d age 14-18y 8 mg/d age ≥19 y Females: 15 mg/d age 14-18y 18 mg/d age 19-50 y Typical (average) intakes 17 mg/d in men 12 mg/d in women
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4 Functions of Fe (pp 539-40) In red blood cells (hemoglobin), muscle (myoglobin) & liver (hemosiderin; cytochromes of enzymes & electron transport chain)
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5 Iron-Deficiency Anemia (pp 541-2) Most common form of anemia, i.e. low [hemoglobin] Signs/symptoms Pale skin Fatigue Developmental delay Susceptible pop’ns Pregnant women People w/ chronic blood loss Vegetarians
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Additional iron needs for pregnancy 250 mg lost at delivery 450 mg for increased RBC Iron-deficiency anemia in pregnancy
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NTR 503 - Wilson Lecture 4 - Nov 4 2010 - students' version...

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