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pps with markups - (6-phosphogluconolactone) irreversible...

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11 Pentose Phosphate Shunt hexose monophosphate shunt 6- phosphogluconate pathway 1. Cytosol 2. Importance a. NADPH reductive biosynthesis (NADH for e to 02) Fatty acid biosynthesis glutathione reductase uses NADPH so that reduced G-SH is available to reduce H202 by GPx Cytochrome P450 for OH addition to compounds Vit D, bile acids, steroid hormones detoxification often with uronides H2O2 formation for phagocytosis NO production muscle relaxation in vascular system-like nitroglycerin reduces platlet aggregation brain neurotransmitter b. ribose formation c. ribose use
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22 3. Tissue location a. Erythrocytes b. Liver c. Adipose d. Adrenal cortex e. Gonads 4. Oxidative Reactions a. G-6-P to 6-P-GL
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Unformatted text preview: (6-phosphogluconolactone) irreversible by G-6-PD (rate-limiting) NADPH Formation inhibited by NADPH induced by insulin b. 6-GP (6-P gluconate) to Ribulose 5-P irreversible NADPH Formation Pentose formed 33 5. Nonoxidative reaction a. Reversible b. 3, 4, 5, 6 & 7 Carbon sugars 1) Ribose -5-P formed for nucleotides 2) F-6-P, G-3-P (could go to ribose) 3) Transketolase 6. G-6-PD Deficiency a. Most common enzyme deficiency disease b. Hemolytic anemia c. Oxidative damage d. RBCs –lowered reduced glutathiones damaged hb (suflhydryl groups) damaged membranes most sensitive No new protein syn. Only NADPH Pathway...
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This note was uploaded on 02/21/2011 for the course NTR 503 taught by Professor Dr.lisa during the Spring '10 term at SUNY Buffalo.

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pps with markups - (6-phosphogluconolactone) irreversible...

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