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Unformatted text preview: (6-phosphogluconolactone) irreversible by G-6-PD (rate-limiting) NADPH Formation inhibited by NADPH induced by insulin b. 6-GP (6-P gluconate) to Ribulose 5-P irreversible NADPH Formation Pentose formed 33 5. Nonoxidative reaction a. Reversible b. 3, 4, 5, 6 & 7 Carbon sugars 1) Ribose -5-P formed for nucleotides 2) F-6-P, G-3-P (could go to ribose) 3) Transketolase 6. G-6-PD Deficiency a. Most common enzyme deficiency disease b. Hemolytic anemia c. Oxidative damage d. RBCs –lowered reduced glutathiones damaged hb (suflhydryl groups) damaged membranes most sensitive No new protein syn. Only NADPH Pathway...
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This note was uploaded on 02/21/2011 for the course NTR 503 taught by Professor Dr.lisa during the Spring '10 term at SUNY Buffalo.
- Spring '10