Term paper on Conjugated fatty acids and Cancer

Term paper on Conjugated fatty acids and Cancer - 1. 2....

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1. Review 2. Conjugated Fatty Acids and Cancer Nitya Reddy Jakka #37039042 3. Abstract Conjugated Fatty acids (CFAs) refer to a group of positional and geometric isomers of polyunsaturated fatty acids which have conjugated double bonds in them. There are several evidences that conjugated fatty acids are effective in treating cancer, obesity, diabetes and hypertension. Of the many forms of CFAs, Conjugated Linoleic Acid (CLA) is considered to be contributing to antitumor activity in cancer. For this reason, it is under serious investigation. Many studies have investigated the possible effects of CLA on carcinogenesis in animal models as well as in cell culture models. Keywords: CFA/ CLA/ Carcinogenesis/ Initiation/ Promotion 1 Introduction 1. Conjugated Fatty Acids Conjugated Fatty Acids (CFAs) are a defined as a class of isomers of poly unsaturated fatty acids, both positional and geometric, with conjugated double bonds. 1
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In theory, a number of CFA isomers are possible, with multiple combinations of numerical, positional and geometrical configurations of conjugation in double bonds. Currently, CFAs have attracted great attention because of their possible beneficial effects of attenuating cancer and other lifestyle-related diseases [1-3]. There are several types of CFAs, both from animal and plant sources [4, 5]. It is assumed that one-third of cancers in humans are associated with dietary habits and lifestyle [6]. The quality of dietary lipids is an important modulator of morbidity and mortality of such diseases [7]. CFAs in particular, as essential fatty acids are very important for the maintenance of biological functions in humans [8]. 1.2 Conjugated Linoleic Acid Conjugated Linoleic acid (CLA) is the conjugated form of Linoleic acid (LA). CLAs are fatty acids that are found naturally in foods derived from ruminant animals. The term Conjugated Linoleic Acid was coined by Ha et al in 1987 when they studied biological activity of CLA in grilled ground beef [9]. Ever since then, the biological properties of CLA have been under study overseeing its possible use in pharmaceuticals, foods and feeds [10]. As stated above, CLAs are found in animal foods such as beef and lamb. They are also found in dairy foods derived from these ruminant sources [11, 12]. They occur naturally in plant lipids in only trace amounts but various CLA isomers have been produced during the process of chemical hydrogenation of fats [13]. 2
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Presently, a lot of interest is being generated on CLAs because it has been established that these modified fatty acids possess anti-cancer properties. This paper attempts to review the potential benefits of CLAs in cancer prevention and the possible mechanisms by which they inhibit carcinogenesis. 2 CLA and Cancer
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This note was uploaded on 02/22/2011 for the course PGY 451 taught by Professor Baizer during the Spring '09 term at SUNY Buffalo.

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Term paper on Conjugated fatty acids and Cancer - 1. 2....

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