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block1-PGY451-awayda - Human Physiology 451/551 Renal...

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Awayda, 2010- PGY451 Human Physiology 451/551 Renal Physiology- Dr. Awayda ( [email protected] , 242 Cary Hall) Lecture Organization (participation encouraged) Ask questions anytime Time at the beginning of lectures to deal with questions Bring your questions to class or to Blackboard Slides available on Blackboard Show up to class
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Awayda, 2010- PGY451 Renal Physiology WHAT IS THE FUNCTION OF THE KIDNEY?
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Awayda, 2010- PGY451 Renal Physiology Main Function: fluid Homeostasis
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Awayda, 2010- PGY451 Renal Functions Transport Regulation of water and inorganic ion balance
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Awayda, 2010- PGY451 Renal Functions Transport Regulation of water and inorganic ion balance e.g., Na + , Cl - , etc. .. Removal of waste byproducts from the blood e.g., Urea, ammonia, creatinine, other non-nitrogenous waste Urea proteins amino acids NH 2 removed ammonia, liver converts to urea Uric acid nucleic acid catabolism Creatinine creatine phosphate catabolism Hormonal Renin 1,25-dihydroxyvitamin D3 Gluconeogenesis
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Awayda, 2010- PGY451 Renal Functions Transport Regulation of water and inorganic ion balance e.g., Na + , Cl - , etc. .. FLUID HOMEOSTASIS
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Awayda, 2010- PGY451 Hypertension Treatment Diuretics ACE/AngII inhibitors ARB Adrenergic Blockers Vasodialators C.O.= S.V. x H.R . (FLUID HOMEOSTASIS) Increase : U Na .V, and/or Uv
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Awayda, 2010- PGY451 Body Fluid Compartments Intracellular ICF Extracellular ECF Plasma Interstitial Other Fluids P
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Awayda, 2010- PGY451 Distribution of Body Water In a typical 70 Kg (156 lbs) individual: Approximately 60% (40L) of body weight is water! 1/3 of this is extracellular (ECF) 2/3 of this is intracellular (ICF)
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Awayda, 2010- PGY451 Fluid Compartments Human Anatomy and Physiology 6th edition, E. Marieb VERY STABLE
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Awayda, 2010- PGY451 Specific Fluid Composition Total Body Volumes (mEq) Plasma Interstitial Intracellular Na + 135-145 135-145 10-30 Cl - 95-105 95-105 10-20 K + 3-5 3-5 120-145 Ca ++ 1-2 1-2 0.0001 Protein 10-20 <1 50 Osmolarity 295 295 295
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Awayda, 2010- PGY451 Electrolyte Composition Modified from: Human Anatomy and Physiology 6th edition, E. Marieb Reversed Na + + Concentrations Very low intracellular Ca ++ ISOTONIC
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Awayda, 2010- PGY451 Organ Systems Affecting Body Fluid Composition Respiratory GI tract Integument Renal Human Anatomy and Physiology 6th edition, E. Marieb SKIN
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Awayda, 2010- PGY451 Reliance on Circulation and Driving Forces All are Epithelia All Limited by Diffusion Distance Diffusion Time Significance 100 Ang 0.0000001 S Cell membrane thickness 1 micron 0.001 sec Size of most bacteria or mitochondria 10 microns 0.1 sec Diameter of small eukaryotic cells 100 microns 10 sec Diameter of large eukaryotic cells 250 microns 1 min Radius of giant squid axon 2 millimeters 1 hr Thickness of frog sartorius muscle, half thickness of lens of eye
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This note was uploaded on 02/22/2011 for the course PGY 451 taught by Professor Baizer during the Spring '09 term at SUNY Buffalo.

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block1-PGY451-awayda - Human Physiology 451/551 Renal...

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