block3rev-pgy451-awayda

block3rev-pgy451-awayda - Block III- Renal Homeostasis...

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Awayda, 2010 -PGY451 Block III- Renal Homeostasis Regulation of Na+ and Water Balance Regulation of K+ Balance Acid-Base Balance
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Awayda, 2010- PGY451 Sodium Balance Evolutionary conservation of water Along with that came the need to conserve Na & Cl- the predominant extracellular ions GI and Urinary systems designed to (re)absorb the majority of Na and hence problems with high salt diets
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Awayda, 2010- PGY451 Response to Changes of Na+ Intake Coupling between Na+ and water Rapid response to an increase of Na+ balance
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Awayda, 2010- PGY451 Reabsorption in Hypervolemia or Hypernatremia
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Awayda, 2010- PGY451 Reabsorption in Hypovolemia or Hyponatremia Highest fractional change in activity in the CCD
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Awayda, 2010- PGY451 Major Determinants of Na+ Excretion GFR- pressure natriuresis and diueresis Aldosterone RAS ANP AVP or ADH
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Awayda, 2010- PGY451 GFR- pressure natriuresis and diueresis Increased Volume or Pressure leads to Increased GFR Increased Filtered Na+ Decreased Reabsorption- Percentage Increased Excretion Water Follows Glomerular tubular balance (GTB): Constant proportion of filtered load reabsorbed in the proximal tubule GTB is not perfect so increased GFR increases urine flow and sodium excretion.
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Awayda, 2010- PGY451 Overall Response to Aldosterone Sustained response
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Awayda, 2010- PGY451 Cellular Effects of Aldosterone Genomic and non-genomic effects
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Awayda, 2010- PGY451 RAS
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Awayda, 2010- PGY451 ADH/AVP Reset Sensitivity- hypertension
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Awayda, 2010- PGY451 ADH/AVP and Water Channels
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Awayda, 2010- PGY451 ADH/AVP and Urinary Osmolarity
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Awayda, 2010- PGY451 ANP/Urodialtin IMCD Medullary Collecting Duct Na + Na + K + ANP cGMP - Lumen Capillary
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Awayda, 2010- PGY451 Mechanisms of Na+ Reabsorption
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Awayda, 2010- PGY451 Na+ Reabsorption by the Nephron
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Awayda, 2010- PGY451 Overall Summary Na+ Excretion
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Awayda, 2010- PGY451 Potassium Balance K+ is a tightly regulated extracellular ion Large intracellular reserve K+ excretion stimulated by many hormones that promote Na+ reabsorption Urinary system designed to excrete K+ rather than to conserve
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Awayda, 2010- PGY451 Response to changes of Extracellular K+ Extracellular K+ balance is maintained by: 1. Intracellular K+ stores 1. Renal K+ handling
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Awayda, 2010- PGY451 Cellular Response to Changes of Extracellular K+ K+-induced depolarization activates insulin secretion
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Awayda, 2010- PGY451 Overall Renal Handling of K+ Reset Sensitivity- hyperkalemia
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This note was uploaded on 02/22/2011 for the course PGY 451 taught by Professor Baizer during the Spring '09 term at SUNY Buffalo.

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block3rev-pgy451-awayda - Block III- Renal Homeostasis...

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