Lecture 2 Cardiac action potentials

Lecture 2 Cardiac action potentials - Lecture 2: Generation...

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Unformatted text preview: Lecture 2: Generation of the Cardiac Action Potential PGY452/552 R. Rasmusson Action potentials arise from current flow across membranes. Current is carried by charged ions in solution. This balanced current flow gives rise to the resting membrane potential. Facts to Know Sodium is in high concentration on the outside. Potassium is at high concentration on the inside. Chloride is at lower concentrations on the inside. Calcium is at very low free concentration on the inside of the cell. Not in the Book Chloride is maintained above equilibrium by electroneutral co-transport in heart. This co-transporter simultaneously moves 1Na-1K and 2Cl ions. The Chloride reversal potential is typically in the range of -40 mV Action potentials come in a variety of shapes and are specialized for various purposes. The cardiac action potential is longer and more complex than the shorter Neuron or Skeletal muscle action potential. Action potentials fire in an all-or-none fashion in response to a stimulus Once an action potential fires it will go though a pre-set sequence of events....
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This note was uploaded on 02/22/2011 for the course PGY 452 taught by Professor Dr.baizer during the Spring '11 term at SUNY Buffalo.

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Lecture 2 Cardiac action potentials - Lecture 2: Generation...

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