Topic 06-Long term stores-S_2011

Topic 06-Long term stores-S_2011 - PGY452/552: Human...

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PGY452/552: Human Physiology: Endocrinology A. Click to edit Master subtitle style 6. Regulation of Long- term Energy Stores A. The issue of balance B. Leptin communicates status C. Other players 1) Insulin 2) Ghrelin A. Hypothalamic integration
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Brave new world of endocrinology Energy is stored as triacylglycerol in the adipose tissue Traditional view Insulin & glucagon regulated CHO metabolism Energy stores regulated by caloric intake Current view Complex endocrine regulation involving the adipose, GI, pancreas & 22
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Why long-term regulation is Modern humans (in the developed world) Food Caloric intake is constant Abundance is the rule Very recent situation More the exception Nearly all the 250,000 years of the species Survival depends on balancing caloric intake with long term energy demands despite long term unknowns 33
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Energy balance: Ein=Eout The simple question for modern humans: How much should we eat? Old days not an issue; eat as much as possible How much energy can it afford to expend & still have enough to long-term needs? Intake Feeding Absorption Expenditure Basal metabolism Thermogenesis Physical activity Stores 44
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Li ve r Mus cle GI Energy signals come from energy Adipose tissue is the main site of stored energy
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This note was uploaded on 02/22/2011 for the course PGY 452 taught by Professor Dr.baizer during the Spring '11 term at SUNY Buffalo.

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Topic 06-Long term stores-S_2011 - PGY452/552: Human...

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