Topic 08-Growth-S_2011

Topic 08-Growth-S_2011 - 8 Growth hormone IGF1 the other...

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1/26/2010 Click to edit Master subtitle style 8. Growth hormone & IGF1: the other face of anabolism A. Growth hormone & IGF1 work together B. Promotion of growth C. Metabolic effects of GH D. Control E. Integration with anabolism
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1/26/2010 A lifetime of metabolic control n Growth is key to survival ¨ Too much: starve ¨ Too little: defense & competition for mates ¨ Lead to reproduction n Critical hormone: Growth hormone (GH) n Major Functions ¨ Metabolic ¨ Growth 2 2
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1/26/2010 The other face of n Long-term storage of energy (fat) n GH ¨ 1 Protein anabolism → skeletal muscle ¨ 1 Lipid catabolism → Adipose 33 Fountain of youth? Perhaps Legal sales of human GH in 2005: $1.1 billion (~50% insulin)
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1/26/2010 GH secreted from the anterior n GH = somatotrophin n 190 amino acid peptide n Secreted by ¨ Somatotrophs in anterior pituitary ¨ Most abundant cell type n Hypothalamic control 44 Hypothalam us
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1/26/2010 55 GH effects on growth are mediated through IGF1 n IGF=insulin-like growth factor ¨ AKA somatomedin ¨ 68 amino acid peptide n IGF1 actually causes growth ¨ Made in most tissues → paracrine or autocrine effects ¨ Liver: major source of circulating IGF1 → endocrine effects (?) n GH receptors widespread but most abundant in the liver
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1/26/2010 n Tyrosine kinase associated receptor n JAK tyrosine kinase n Transcriptional regulation n IGF1 similar to insulin n Receptor tyrosine kinase (RTK) n Diverse signaling n Similar to insulin 66 IGF 1 Receptors suggest Growth Hormon e T K T K J A K J A K
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1/26/2010 GH & IGF1 binding proteins n Growth hormone BP ¨ Soluble fragment of its receptor ¨ 30-40% bound ¨ t½ ≈ 20 min ¨ Long for a peptide n IGF1 binding proteins n Family of distinct proteins ¨ Can interact with membrane ¨ Mediate 77 I G F I G F I G F I G F I G F 2 G H J A K G H J A K TK TK
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1/26/2010 IGF1: Bone growth The difference is two amino acids in the IGF1 receptor IGF1: secreted from & stimulates dividing chondrocytes in the epiphyseal plate Epiphys is Diaphy sis Bone growth Dividing chondrocytes Epiphyseal plate Epiphyseal plate closed by estrogen → 88
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This note was uploaded on 02/22/2011 for the course PGY 452 taught by Professor Dr.baizer during the Spring '11 term at SUNY Buffalo.

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Topic 08-Growth-S_2011 - 8 Growth hormone IGF1 the other...

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