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Topic 12-Fluids & electrolytes-S_2011

Topic 12-Fluids & electrolytes-S_2011 - 12...

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Click to edit Master subtitle style 12. Endocrine regulation of fluid & ions A. Antidiuretic Hormone (ADH) B. Angiotensin II C. Aldosterone D. Integration
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Fluid and electrolyte levels are carefully regulated n Electrolytes in ECF ¨ Na+: 135-145 mM ¨ K+: 3.5-5.0 mM ¨ Osmolarity: 280-296 mOs n More complex than just endocrine factors n Regulation ¨ Kidney: water & ions ¨ Vasculature: blood pressure or volume 22 Hormones ADH Angiotensin II Aldosterone
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Antidiuretic hormone n ADH or Vasopressin n Posterior pituitary ¨ Synthesized in hypothalamus ¨ Axons extend to posterior pituitary ¨ Blood supply n Regulation ° neural inputs n 9 amino acid peptide n Receptors ¨ Gαq-coupled receptor in vasculature ¨ Gαs in kidney Major effect : Water conservation 33 hypothalami c receptors ADH
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ADH is secreted in response to sensory input 44 pressure / volume [water] A D H ADH [water] (osmolarity) is key input thirst [water] [ pressure / volume
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ADH in the kidney conserves water 55 Lumen Blood H2 0 s AD H A Q P n ADH binds to Gαs-coupled receptor n Stimulates aquaporin ¨ Transcription ¨ Transport P K A A C cA MP
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ADH in the vasculature ± blood pressure & volume 66 q AD H IP 3 Contraction n Interacts with Gαq receptor n Ca2+ release results in muscle contraction n Increase blood pressure by decreasing vascular volume Mostl y respo nse to sever Ca 2 + PL C PL C
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