Topic 15-Females-S_2011

Topic 15-Females-S_2011 - 15. Female reproductive...

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Click to edit Master subtitle style 2/7/2008 Physiology 452/552; Endocrinology, Dr. 15. Female reproductive endocrinology A. Hypothalamic-pituitary control B. Development C. The two cycles D. Hormone secretion & feedback control during the cycles E. Onset of pregnancy
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22 The hormones should sound familiar n Gonadotropin Releasing Hormone (GnRH) n LH & FSH n Inhibin n Estrogens q Enhance cell proliferation n Progesterone q Inhibit cell proliferation n Complex patterns of expression
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Childhood GnRH in females n Same function as in males n Expression increases with age n During puberty q Higher at night q Pulsatile at only at night in adolescents n During reproductive years the pulsatile pattern persists during the day q Unlike males, pattern very regular at ~1/hr Day Nigh t Puberty Adult Menopause 33
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2/7/2008 Physiology 452/552; 44 LH & FSH levels vary with age 2nd trimester Birt h Age 10- 14 >50 years FS H L H FSH surge that begins puberty LH varies more & is in higher concentration during reproductive years Plasma [gonadotropin] Monthly
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55 GnRH, FSH, and LH control the menstrual cycle n Purpose q To ensure the maturity of a single oocyte in preparation for fertilization q Prepare the uterus to implant the fertilized egg n Tissues q Ovaries q Endometrial wall of the uterus n Two cycles q Ovarian q Endometrial q Ovulation is at the midpoint of each cycle Uter us Ov ary Cer vix Endometria l wall Fallopian tube Folli cle
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Maturation of the oocyte occurs in 66 n Early tertiary follicle (~10 days) n Similar to seminiferous tubule, except q One germ cell q Lives 28 days q Extensive development during cycle n theca ≈ Leydig→ androgens n granulosa ≈ Sertoli → estrogens granulosa cells=Sertoli cells theca cells=Leydig cells Maturin g oocyte
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The ovarian cycle n Lasts 28 days n Two phases q Follicular phase q Luteal phase n All under endocrine control 1. At the beginning of the cycle, a cohort of follicles is recruited 2.
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This note was uploaded on 02/22/2011 for the course PGY 452 taught by Professor Dr.baizer during the Spring '11 term at SUNY Buffalo.

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Topic 15-Females-S_2011 - 15. Female reproductive...

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