Topic 16-Lactation-S_2011

Topic 16-Lactation-S_2011 - (dopamine) n Synthesized by...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
2/10/2011 Click to edit Master subtitle style 16. Lactation A. Oxytocin B. Prolactin C. Feedback
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2/10/2011 Lactation Smooth muscle ejects milk Secretory lobule Alveoli Milk Alveolar cells produce milk 22
Background image of page 2
2/10/2011 Oxytocin is a Posterior Pituitary Hormone n Secreted from neurons in the hypothalamus n Related to ADH n Regulation requires neural inputs n Small peptide: 9 amino acids Released into  general  circulation Vesicles stored in  posterior pituitary  Hormones secreted from  large neurons 33
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2/10/2011 Oxytocin n Targets secretory lobule smooth muscle ¨ Uterus smooth muscle contraction ¨ As neurotransmitter related to affection & attachment n Milk ejection through muscle cell contraction n Works through G protein coupled receptor 44
Background image of page 4
2/10/2011 Oxytocin works through a G q α q IP 3 Contraction Oxy PL C PL C Ca 2+ 55
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2/10/2011 Back to the Anterior Pituitary: Prolactin n Peptide similar structure to GH n Therefore its receptor is similar: JAK/STAT TK n Modifies gene expression to qmilk production n Neural inputs dominate regulation ¨ Prolactin inhibiting hormone
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (dopamine) n Synthesized by same pathway as epinephrine from Tyr n Receptor Gαi coupled ¨ Prolactin releasing hormone undiscovered & unnecessary (?) O H C H 2 C H N H 2 H O H Dopamin e ST A T J A K P L 66 2/10/2011 Regulation by PI H PL Milk synthesis E GnRH Contraction TR H Suckling activates touch receptors in nipple Maternal emotional response L H FS H LH/FSH stops menstrual cycle Ox y 77 Summary: Lactation n Positive feedback mechanism ¨ Suckling → Oxytocin → Milk → Suckling ¨ Effects on GnRH→LH/FSH The Hormones (*N/A=not applicable) Hormone Source Type t½ Rcpt Stimulus Inhibition Major Effects Other Oxytocin Posterior pituitary Peptid e shor t Gq Touch ↓touch ↑contraction alveolar smooth muscle Emotional Prolactin Anterior pituitary Glyco-protei n shor t JAK Touch estroge ns TSH PIH ↑milk, ↓GnRH ↑ sex steroids PIH (dopamine) Hypo-thalamus Amid e shor t Gi N/A touch ↓ prolactin ↓ TSH 88...
View Full Document

This note was uploaded on 02/22/2011 for the course PGY 452 taught by Professor Dr.baizer during the Spring '11 term at SUNY Buffalo.

Page1 / 8

Topic 16-Lactation-S_2011 - (dopamine) n Synthesized by...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online