3_antibacterial - Anti microbial agents lectures 1...

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1 Anti microbial agents lectures 1 [email protected] Home page: http://www.medicine.mcgill.ca/pharma/mszyflab/ Drug discovery and development serendipity observation use Clinical effects Adverse effects misuse mechanism Selective toxicity Goal: Study the pathogen and identify potential specific weak spots
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2 Questions to be addressed What is the clinical target? How does the drug act on its clinical target? Does the drug get there (pharmacokinetics)? How does the target react to the drug (resistance)? What are the untoward effects? How do they relate to the mechanism of action? What are the structural features responsible for the above? ciprofloxacin Bacterial specific targets DNA mRNA wall Protein synthesis Penicillin G Ampicillin Methicillin Cephalosporins Vancomycin Clavulanic acid PABA DHFA THFA sulfonamides trimethoprim Chloramphenicol erythromycin Tetracyclines aminoglycosides rifampin Clinical use of antibiotics *empirical therapy *definite therapy *prophylactic therapy Dilution test Antibacterial concentration( µ g/ml) Determining the minimal inhibitory concentration, MIC And the minimal bactericidal concentration MBC
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3 How do we determine the sensitivity of a bacteria to an antibacterial agent? Drug impregnated disks R S Two modes of action of anti-bacterials bactericidal bacteriostatic immunocompetent immunocompromised
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