5_antiviral

5_antiviral - The genetic information of viruses is encoded...

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1 Antiviral Drugs Antiviral drugs are discussed in Brody chapter 51 The genetic information of viruses is encoded in either RNA or DNA in different states the machinery responsible for synthesizing the genetic information of viruses is a prime target for antiviral drugs DNA viruses, replication and targets Structural proteins Viral enzymes Regulatory proteins Assembly Of virion ribosomes budding attachment Uncoating Transfer of DNA Viral DNA Viral RNA Viral DNA replication Acyclovir,vidarabine,ganciclovir X Protease inhibitors X ribavirin x amantidine x CD4 decoy X Therapeutic window IC50 cellular IC50 viral
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2 ACYCLOVIR dGMP GANCICLOVIR Acyclovir and ganciclovir analogs of guanosine DNA chain elongation Incoming trinucleotide phosphate Acyclovir causes chain termination
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Clinical use of acyclovir most widespread use of acyclovir is in the treatment of genital HSV infections acyclovir is ineffective in eliminating latent infection Topical treatment beneficial in primary genital HSV infections and in mucocutaneous HSV infections in immunocompromised hosts. Clinical use of ganciclovir oral bioavailability is low CMV retinitis in immunosuppressed patients prevention of CMV disease in transplant recipients Adverse effects of ganciclovir profound bone marrow suppression particularly neutropenia Bone marrow toxicity is potentiated
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5_antiviral - The genetic information of viruses is encoded...

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