6_epilepsy

6_epilepsy - 1 PHAR 301 DRUGS AND DISEASE EPILEPSY Paul...

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Unformatted text preview: 1 PHAR 301 DRUGS AND DISEASE EPILEPSY Paul Clarke Pharmacology and Therapeutics [email protected] Brody 5th edition Chapter 34 Treatment of seizure disorders In Brody you can safely ignore Reading In Brody, you can safely ignore: • All anti-seizure drugs that are not mentioned in the lecture • Lennox-Gestaut Syndrome Drugs to know by name carbamazepine (Tegretol™) phenytoin (Dilantin™) valproate or valproic acid (Dekapene™) ethosuximide (Zarontin™) phenobarbital diazepam (Valium™) MK-801 Commercial names (in brackets) are mainly for interest Commercial names are capitalized, generic names are not The ™ symbol means trade mark Names of people mentioned in lecture need not be memorized Seizures are temporary alterations in brain function associated with a changed mental state, tonic or clonic movements and/or various other symptoms. They are due to abnormal electrical activity in the brain. Seizures, convulsions, and fits - definitions Convulsions are seizures always accompanied by involuntary jerking movements of the body Fit- an older term for a seizure 2 What is epilepsy? Volts EEG before, during and after a clonic convulsion Time Partial Two basic kinds of seizures Generalized EPILEPSY PARTIAL focus GENERALIZED whole brain Note: this is a simplified scheme SIMPLE COMPLEX Sensory ± Motor Temporal Lobe Aura Automatism TONIC-CLONIC "Grand mal" ABSENCE "Petit mal" Unconsciousness No balance Hypoxia 3 Hz EEG 301B epilepsy.sdr 3 Simple partial seizures: symptoms depend where the focus is EPILEPSY PARTIAL focus GENERALIZED whole brain Note: this is a simplified scheme SIMPLE COMPLEX Sensory ± Motor Temporal Lobe Aura Automatism TONIC-CLONIC "Grand mal" ABSENCE "Petit mal" Unconsciousness No balance Hypoxia 3 Hz EEG 301B epilepsy.sdr Complex partial seizures • usually affects temporal lobe • consciousness is lost or impaired • preceded by aura • simple "automatisms" or complex "psychomotor attack" • commonest subtype of epilepsy EPILEPSY PARTIAL focus GENERALIZED whole brain Note: this is a simplified scheme SIMPLE COMPLEX Sensory ± Motor Temporal Lobe Aura Automatism TONIC-CLONIC "Grand mal" ABSENCE "Petit mal" Unconsciousness No balance Hypoxia 3 Hz EEG 301B epilepsy.sdr 4 EPILEPSY PARTIAL focus GENERALIZED whole brain Note: this is a simplified scheme...
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This note was uploaded on 02/22/2011 for the course PHAR 301 taught by Professor Hales during the Spring '11 term at McGill.

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6_epilepsy - 1 PHAR 301 DRUGS AND DISEASE EPILEPSY Paul...

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