8_cancer - Anticancer Drugs Part 2 Barbara Hales Phar 301...

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1 Anticancer Drugs Part 2 Barbara Hales McGill University Phar 301 Chemotherapeutic drugs Anti- metabolites Alkylating agents Anti-tumor antibiotics Cyclophosphamide Cisplatin Methotrexate 5-Fluorouracil Cytarabine Vincristine Vinblastine Taxol Doxorubicin Etoposide Bleomycin Hormonal agents Other Targeting microtubules Vincristine Vinblastine Taxol
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2 Vinca alkaloids Periwinkle leaves (Vinca Rosea) Vinca alkaloids: vinblastine, vincristine Bind to tubulin, terminate assembly and cause depolymerization of microtubules and mitotic arrest Taxanes Pacific yew tree Promote microtubule assembly and inhibit disassembly Abraxane: Paclitaxel in albumin-coated nanoparticles FDA approved this nanoparticle drug in Jan. 2005 for use in metastatic breast cancer
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3 Anti-tumour Antibiotics: Doxorubicin 1) Inhibits topoisomerase II 2) Intercalates DNA, blocking DNA and RNA synthesis 3) Alters cell membrane fluidity and ion transport 4) Generates free radicals Bone marrow and cardiac toxicity
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This note was uploaded on 02/22/2011 for the course PHAR 301 taught by Professor Hales during the Spring '11 term at McGill.

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8_cancer - Anticancer Drugs Part 2 Barbara Hales Phar 301...

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