11_immunosuppression

11_immunosuppression - 1 Immunosuppression Barbara Hales...

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Unformatted text preview: 1 Immunosuppression Barbara Hales McGill University PHAR 301 Drugs and Disease Chapter 6 Antibodies and Biological Products Components of the immune system Components of the Immune system 2 Innate Immunity vs. Acquired Immunity Acquired Characteristic Innate Immunity Acquired Immunity Onset of action Immediate Days to weeks Mechanism of Receptors that recognize common Unique antigen specific receptors Goal: to recognize and remove invading microorganisms and tumor cells Immune response antigen recognition molecules on microbes and viruses (T-cell receptor, B cell receptor) Cell types/factors Macrophages, neutrophils, mast cells, natural killer cells, complement, interferon Antigen presenting cells, T- lymphocytes, B-lymphocytes Acquired immunity Antigen-specific activation of nave T cells Activated T cells generate effector Th1 and Th2 cells 3 Cell Mediated Immunity Lysis of tumor cells, virally infected cells, graft/transplant cells Humoral immunity Th2 cells stimulate B cells to produce Ab-secreting plasma cells Stimulation of the immune response IL-2 Interferons GM-CSF Decreased cell proliferation Enhanced immune activities 4 Suppression of the Immune System? 1. Prevent rejection of organ transplants 2 Treat autoimmune disorders 2. Treat autoimmune disorders 3. Prevent Rh hemolytic disease of the newborn. Organ transplants Kidney transplant rejection Organ transplant rejection 1.Hyperacute- necrosis within minutes to hours- pre-existing antibodies 2. Acute- days to months- main barrier to allotransplantation- T-cell recognition of transplanted tissue 3. Chronic- months to years 5...
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This note was uploaded on 02/22/2011 for the course PHAR 301 taught by Professor Hales during the Spring '11 term at McGill.

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11_immunosuppression - 1 Immunosuppression Barbara Hales...

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