lecture_11 - Protein Secondary Structure II Lecture...

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Protein Secondary Structure II Lecture 2/24/2003
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Principles of Protein Structure Using the Internet Useful online resource: http://www.cryst.bbk.ac.uk/PPS2/ Web-based protein course
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Structural hierarchy in proteins
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The Polypeptide Chain
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Peptide Torsion Angles Torsion angles determine flexibility of backbone structure
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Rammachandran plot for L amino acids Indicates energetically favorable φ / ψ backbone rotamers
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Steric hindrance limits backbone flexibility
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Side Chain Conformation
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Sidechain torsion rotamers named chi1, chi2, chi3, etc . e.g. lysine
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chi1 angle is restricted Due to steric hindrance between the gamma side chain atom(s) and the main chain The different conformations referred to as gauche (+), trans and gauche (-) gauche (+) most common
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Regular Secondary Structure Pauling and Corey Helix Sheet
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A repeating spiral, right handed (clockwise twist) helix pitch = p Number of repeating units per turn = n d = p/n = Rise per repeating unit Fingers of a right - hand. Several types
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_11 - Protein Secondary Structure II Lecture...

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