lecture_12a - Protein Structure Lecture 2/26/2003 beta...

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Protein Structure Lecture 2/26/2003
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beta sheets are twisted Parallel sheets are less twisted than antiparallel and are always buried. In contrast, antiparallel sheets can withstand greater distortions (twisting and beta- bulges) and greater exposure to solvent.
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The twist is due to chiral (l)- amino acids in the extended plane. This chirality gives the twist and distorts H- bonding. A tug of war exists between conformational energies of the side chain and maximal H- bonding.
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Two proteins exhibiting a twisting β sheet Bovine carboxypeptidase Triose phosphate isomerase
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Connections between adjacent β sheets
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Sheet facts Repeat distance is 7.0 Å R group on the Amino acids alternate up-down-up above and below the plane of the sheet 2 - 15 amino acids residues long 2 - 15 strands per sheet Ave of 6 strands with a width of 25 Å parallel less stable than anti-parallel Anti-parallel needs a hairpin turn Tandem parallel needs crossover connection which has a right handed sense
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_12a - Protein Structure Lecture 2/26/2003 beta...

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