lecture_12b - Protein Structure Lecture 2/26/2003 Protein...

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Protein Structure Lecture 2/26/2003
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Protein Structures A study in the structure-function of proteins. Amino acid sequence dictates function. Structures are not “static” but breath and vibrate Protein dynamics (movement) can be linked to function
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Globular proteins = enzymes and catalysts Fibrous proteins = structural or connective role. Structure - function relationships Some residues and chains are just disordered “Floppy” flexible which maybe required for function
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Nails, hair, horns and feathers α or β forms 30 variants, tissue specific type I and type II acidic negative charge basic positive charge α keratin - hair- 20 μ M diameter macrofibril 2000 Å parallel to hair microfibril 80 Å and high sulfur cement protein. Fibrous (structural) proteins Keratin
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α keratin proteins are helical but spacing differs from an α helix a 5.1 Å vs. 5.4 Å pitch. This change in pitch forms closely associated pairs of helices. Each pair consists of a type I and type II protein Left-handed coil coiled-coil 310 AA residues 7-residue pseudo repeat. Helical wheel - Look down an
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lecture_12b - Protein Structure Lecture 2/26/2003 Protein...

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