lecture_23a - The Citric acid cycle 4/16/2003 The Citric...

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The Citric acid cycle 4/16/2003
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The Citric acid cycle It is called the Krebs cycle or the tricarboxylic and is the “hub” of the metabolic system. It accounts for the majority of carbohydrate, fatty acid and amino acid oxidation. It also accounts for a majority of the generation of these compounds and others as well. Amphibolic - acts both catabolically and anabolically 3NAD+ + FAD + GDP + Pi + acetyl-CoA 3NADH + FADH + GTP + CoA + 2CO 2
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History By 1930 it was established that the addition of lactate, acetate succinate, malate, α -ketoglutaric acid (dicarboxylic acids) and citrate and isocitrate (tricarboxylic acids) when added to muscle mince that they stimulated oxygen consumption and release of CO 2 1935Albert Szent-Gyorgyi showed that Succinate Fumarate Malate Oxaloacetate Carl Martius and Franz Knoop showed Citrate cis-aconitate isocitrate α ketoglutarate succinate fumarate malate oxaloacetate
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Martius and Knoop showed that pyruvate and oxaloacetate could form citrate non-enzymatically by the addition of peroxide under basic conditions. Krebs showed that
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_23a - The Citric acid cycle 4/16/2003 The Citric...

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