lecture_24 - The Citric Acid Cycle II and the Pentose...

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The Citric Acid Cycle II and the Pentose Phosphate Pathway 4/22/2003
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The Citric acid cycle 3NAD+ + FAD + GDP + Pi + acetyl-CoA 3NADH + FADH + GTP + CoA + 2CO 2 Overall reaction
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Overview
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24 E2 subunits 24 E1 orange a and b together 12 E3 Red EM based image of the core E2 from yeast pyruvate dh
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Domain structure of dihydrolipoyl transacetylase E2
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S S E 2 H S S E 2 S S H E 2 S S E 2 S S E 2 S S H E 2 H S S E 2 S S E 2 CH 3 O CH 3 O CH 3 O CH 3 O Acetyl reaction center transferes though the E2 dihydrolipoyl coenzyme repeats
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Citrate Synthase HO CH 2 O C HO O O H 3 C C SCoA O + HO CH 2 O C OH O HO CH 2 HO O
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Induced fit needs binding of oxaloacetate before Acetyl CoA can bind . CoAS C OH CH 2 CH 3 C CoAS O CoAS CoAS CH 3 C O OH CH 2 O CH 2 Proposed intermediate Acetyl-CoA Acetonly CoA Carboxymethyl-CoA (ground-state analog) (transition state analog)
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Aconitase HO CH 2 O C OH O HO CH 2 HO O HO CH 2 O CH OH O CH HO O Citrate Cis-Aconitate HO CH 2 O HC OH O C HO O H HO Isocitrate The double bond is placed on the Pro-R arm
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NAD + - Dependent Isocitrate dehydrogenase NAD + NADH
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α -Ketoglutarate dehydrogenase HO CH 2 O H 2 C C HO O O CoAS O HO CH 2 O CH 2 CO 2 This enzyme is just like pyruvate dehydrogenase, a multi enzyme complex that is specific for longer CoA derivatives NAD + NADH
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succinate thiokinase
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_24 - The Citric Acid Cycle II and the Pentose...

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