lecture_25 - Gluconeogenesis Evaluations Overview of...

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Gluconeogenesis + Evaluations 4/23/2003
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Overview of Glucose Metabolism
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Gluconeogenesis Gluconeogenesis is the process whereby precursors such as lactate, pyruvate, glycerol, and amino acids are converted to glucose. Fasting requires all the glucose to be synthesized from these non-carbohydrate precursors. Most precursors must enter the Krebs cycle at some point to be converted to oxaloacetate. Oxaloacetate is the starting material for gluconeogenesis
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Pyruvate is converted to oxaloacetate before being changed to Phosphoenolpyruvate 1. Pyruvate carboxylase catalyses the ATP-driven formation of oxaloacetate from pyruvate and CO 2 2. PEP carboxykinase (PEPCK) concerts oxaloacetate to PEP that uses GTP as a phosphorylating agent.
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Pyruvate carboxylase requires biotin as a cofactor
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Gluconeogenesis is not just the reverse of glycolysis Several steps are different so that control of one pathway does not inactivate the other. However many steps are the same. Three steps are different from glycolysis.
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_25 - Gluconeogenesis Evaluations Overview of...

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