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Unformatted text preview: 1 Amino Acids ( 9/08/2009) 1. What are Amino Acids, and what is their 3-D structure? 2. What are the structures & properties of the individual amino acids? 3. What is the peptide bond? 4. Do amino acids have specific Acid-Base properties? 5. Are small peptides physiologically active? Amino Acids The building blocks of proteins α-amino acids because of an amino group next to the C α R group - determines the identity of the particular amino acid Stereochemistry - important property Amino acids are Ampholytes pK 1 ≈ 2.2 while pK 2 ≈ 9.4, pK R for R group pK’s In the physiological pH range, both NH 2 and COOH are completely 2 ionized They can act as either an acid or a base They are Zwitterions , molecules having charged groups of opposite polarity Because of their ionic nature they have extremely high melting temperatures Amino Acids You must know: Their names Their structure Their three letter code Their one letter code Tyrosine, Tyr, Y, aromatic, hydroxyl Classification and Characteristics of Amino Acids R polarity: three main categories to describe amino acids: 1) Non polar “hydrophobic” nine in all Glycine, Alanine, Valine, Leucine, Isoleucine, Methionine, Proline, Phenylalanine and Tryptophan 2) Uncharged polar, six in all Serine, Threonine, Asparagine, Glutamine, Tyrosine,...
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- Spring '08
- Amino Acids, Amino Acids amino