lecture_25legge - The Citric acid cycle The Citric Acid...

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1 The Citric Acid Cycle II 11/17/2009 The Citric acid cycle It is called the Krebs cycle or the tricarboxylic and is the “hub” of the metabolic system. It accounts for the majority of carbohydrate, fatty acid and amino acid oxidation It also accounts for a majority of the oxidation. It also accounts for a majority of the generation of these compounds and others as well. Amphibolic - acts both catabolically and anabolically 3NAD+ + FAD + GDP + Pi + acetyl-CoA 3NADH + FADH 2 + GTP + CoASH + 2CO 2 Overview The citric acid cycle enzymes are found in the matrix of the mitochondria Substrates have to flow across the outer and inner parts of the mitochondria Pyruvate dehydrogenase A multienzyme complexes are groups of non covalently associated enzymes that catalyze two or more sequential steps in a metabolic pathway . E. coli yeast Pyruvate dehydrogenase -- E1 24 60 dihydrolipoyl transacetylase --E2 24 60 dihydrolipoyl dehydrogenase--E3 12 12 Molecular weight of 4,600,000 Da
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2 24 E2 subunits 24 E1 orange a and b together 12 E3 Red EM based image of the core E2 from yeast pyruvate dh 60 subunits associated as 20 cone-shaped trimers that are verticies of a dodecahedron Why such a complex set of enzymes?
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_25legge - The Citric acid cycle The Citric Acid...

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