lecture_28legge - TCA & Pentose Phosphate Pathway...

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1 TCA & Pentose Phosphate Pathway 12/01/2009 Citrate Synthase HO CH 2 O C HO O O H 3 CC SCoA O + HO CH 2 O C OH O HO CH 2 HO O Induced fit needs binding of oxaloacetate before Acetyl CoA can bind . CoAS C OH CH 2 CH 3 C CoAS O Proposed intermediat Acetyl-CoA CoAS CoAS CH 3 C O OH CH 2 O CH 2 Proposed intermediate Acetyl CoA Acetonly CoA Carboxymethyl-CoA (ground-state analog) (transition state analog) Aconitase - O CH 2 O C O - O HO CH 2 - O CH 2 O O - O - O CH 2 O CH O - O C H HO Pro-S - O O - O O Citrate Cis-Aconitate - O O Isocitrate The double bond is placed on the Pro-R arm Pro-R NAD + - Dependent Isocitrate dehydrogenase NAD + NADH
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2 α -Ketoglutarate dehydrogenase HO CH 2 O H 2 C HO CH 2 O CO 2 NAD + C HO O O CoA SO CH 2 This enzyme is just like pyruvate dehydrogenase, a multi enzyme complex that is specific for longer CoA derivatives NADH Refresh:The five reactions of the pyruvate dehydrogenase multi enzyme complex Succinyl-CoA Synthetase or succinate thiokinase Note symmetry Succinate dehydrogenase HO O HO CH 2 O CH 2 HO O HO CH O CH + 2e - + 2H + The FAD on the enzyme itself is reduced Succinate dehydrogenase is the only membrane bound enzyme in the citrate cycle O O H 3 CO H 3 CO CH 3 CH 2 CH 3 n n = 6-10 Succ dh --FADH 2 + OH OH H 3 CO H 3 CO CH 3 CH 2 CH 3 n Ubiquinone or Coenzyme Q Oxidized form Reduced form Fumarase
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3 Malate dehydrogenase HO H 2
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This note was uploaded on 02/22/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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lecture_28legge - TCA & Pentose Phosphate Pathway...

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