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KIN110 Lec. 26 - Kinesiology 110 Spring 2009 Lecture 26...

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Kinesiology 110 Spring 2009 Professor Braun Lecture 26 questions 1. What are the components of human blood? - Erythrocytes o Red blood cells for transporting oxygen through the body - Leukocytes o White blood cells of the immune system - Platelets o Cell fragments that assist in blood clotting - Plasma o The fluid portion of the blood 2. What % of blood is red blood cell? In men? In women? - Red blood cells account for 41-46% of total blood volume o Women :41-44% o Men: 43-46% 3. What do red blood cells do (primarily)? - Delivering oxygen from the lungs to other tissues in the body o Contain a lot of protein hemoglobin - Hemoglobin is a tetramer o 4 single proteins joined into a 3-dimentional structure (‘globin”) with an iron- containing ring in the center (“heme”) 4. What is anemia? what can cause it? - Red cblood cell synthesis occurs in bone marrow - Two events need to be coordinated o Synthesis of hemoglobin o Cell division to do this, you need iron, B6, Copper, zinc, amino acids, DNA, folic acid (folate) and vitamin B12 to be available in the right quantities - If DNA synthesis is too slow, cells don’t divide enough times o Large red blood cells that break easily Macrocytic (big cell) anemia o Anything that interferes with DNA synthesis will cause macrocytic anemia ***** folate or vitamin B12 deficiency ****** - If hemoglobin synthesis is too slow, cells divide too many times 1
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