This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: 2 b) The product of the following reaction is the biologically active diterpene forskolin. The reaction shown below was a key step in the generation of the forskolin skeleton. Suggest a mechanism for this reaction. O O O O 1) K 2 CO 3 , EtOH 2) pTsOH, C 6 H 6 O O H O 3. Synthesis questions. Undergraduates choose one question and graduate students do two. (8 pts.) a) The structure shown below was a key precursor to a synthesis of equisetin, a fungal metabolite with antibiotic, HIV, and anti-cancer activity. Choose two alkenes and show reagents that could be combined to form these alkene bonds. The best solution will attempt to control alkene stereochemistry. O O S-t-Bu b) Show two steps that will convert the starting material on the left to the product on the right. O OH PMBO CO 2 H OPMB HO 2 C...
View Full Document