Lecture 5 and 6-synaptic transmission

Lecture 5 and 6-synaptic transmission - Synaptic...

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1 Synaptic transmission – an overview: (1) Types of synapses (1) Electrical: gap junction (2) Chemical: better understood, see below for details (2) Chemical synapses (1) Anatomical categorization (1) Axosomatic: tends to be inhibitory (2) Axodendritic: tends to be excitatory (3) Axoaxonal: regulates release (4) Dendrodendritic and dendrosomatic: less common (2) Functional categorization (1) Excitatory: postsynaptic density (PSD) (2) Inhibitory: symmetric, no PSD (3) Modulatory: GPCR (3) Information flow cycle across synapse (1) Transmitter release (1) AP-triggered Calcium entry (2) Vesicle fusion and recycling (3) Loading vesicles by transporters from cytosol (mention synthesis) (2) Neurotransmitters (1) Reuptake: by the neuron releasing it, by glial cells (2) Degradation: by glial cells or neurons (3) Diffusion (3) Receptors (1) Glutamate: EPSP, ionotropic vs metabotropic (2) GABA and glycine: IPSP, ionotropic vs metabotropic (3) Biogenic Amines and Ach: their regulatory roles (4) Synaptic Integration (5) Firing and transmission of axon potential
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2 Synapse: communication juncture
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3 Soma and Dendrites (receiving chemical inputs) Axon (generate electrical output to control chemical release) Neuron doctrine : neurons are the information processing units of the nervous system. Synaptic integration The Next Neuron
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4 Types of Synapses: (1) Electrical Synapse (gap junction) (2) Chemical Synapse (involving neurotransmitters) Electrical Synapse: • fast (no delay) • bidirectional • permeable up to 1 kDa • used to synchronize network • can be regulated Fig. 6-1A
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5 Fig. 6-9 BL
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