Midterm 1 Problems - 2006 - UC Berkeley, Chem C130/MCB...

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UC Berkeley, Chem C130/MCB 100A, Fall 2006, Mid-term Exam. Your Name___________________________ Page 1 of 16 UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A MIDTERM EXAMINATION #1. SEPTEMBER 26, 2006 INSTRUCTOR: John Kuriyan THE TIME LIMIT FOR THIS EXAMINATION IS 1 HOUR AND 20 MINUTES SIGNATURE: _________________________________________________________________ Please SIGN your name ( in indelible ink ) on the line above. YOUR NAME: ________________________________________________________________ Please PRINT your name ( in indelible ink corner of every page). Also, please write all of your answers as legibly as possible . PLEASE CIRCLE THE NAME OF THE GSI FROM WHOM YOU WILL PICK UP YOUR GRADED MID-TERM EXAM: Natasha Keith Kyle Simonetta Jonas Lee James Fraser Allen Liu This exam consists of 5 questions, each worth 20 points total, as indicated below, for a total of 100 points. This exam counts for 200 points out of the final score of 1100 for the course, and so your score on this exam will be multiplied by 2.0 when the final score is calculated. Question Part A Part B Part C Part D Part E Your Total Maximum Score 1. (10) (4) (6) --------------- ----------------- 20 2. (5) (6) (5) (4) --------------- 20 3. (12) (4) (4) --------------- --------------- 20 4. (12) (8) ------------- ------------- -------------- 20 5. (20) --------------- --------------- --------------- --------------- 20 TOTAL ---------- ---------- ---------- ----------- ---------- 100
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UC Berkeley, Chem C130/MCB 100A, Fall 2006, Mid-term Exam. Your Name___________________________ Page 2 of 16 Q1 A (10 points). In the schematic diagram shown below, the nucleotide labeled A forms two hydrogen bonds with the major groove edge of two DNA nucleotides, labeled B and C. The bases of B and C occupy the space indicated by the box. (i) What is the name of the nucleotide labeled A? (2 points) (i) What are the nucleotides labeled B and C? (2 points) (ii) Draw the chemical structure of the Watson-Crick basepair formed by B and C clearly, indicating all hydrogen bonds. Hydrogen bonds made between A and B are indicated by dashed lines. (6 points)
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UC Berkeley, Chem C130/MCB 100A, Fall 2006, Mid-term Exam. Your Name___________________________ Page 3 of 16 Q1B. (4 points) In the schematic diagram shown below, the amino acid sidechains labeled B and C form a hydrogen bonded ion pair. A third sidechain, labeled A, forms hydrogen bonds with both B and C, as indicated. (i) What are the names of the sidechains labeled B and C? For each sidechain provide the full name, the three letter code and the single letter code. (2 points) (ii) Draw the chemical structure for a reasonable choice for sidechain A. (2 points)
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UC Berkeley, Chem C130/MCB 100A, Fall 2006, Mid-term Exam. Your Name___________________________ Page 4 of 16 Q1C. (6 points) In the diagram shown below, two amino acid sidechains, labeled A and B, are shown interacting with the two ends of an α helix, as indicated. (i)
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Midterm 1 Problems - 2006 - UC Berkeley, Chem C130/MCB...

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