Midterm 1 Problems - 2007 - UC Berkeley, C hem C130/MC B...

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UC Berkeley, Chem C130/MCB 100A, Fall 2007, Mid-term Exam 1. Your Name___________________________ Page 1 of 15 UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A MIDTERM EXAMINATION #1. SEPTEMBER 25, 2007 INSTRUCTORS: John Kuriyan and Bryan Krantz THE TIME LIMIT FOR THIS EXAMINATION IS 1 HOUR AND 20 MINUTES SIGNATURE: ________________________________________________________________ Please SIGN your name ( in indelible ink ) on the line above. YOUR NAME: ________________________________________________________________ Please PRINT your name ( in indelible ink ) on the line above (& on the top right hand corner of every page). Also, please write all of your answers as legibly as possible . PLEASE CIRCLE THE NAME OF THE GSI FROM WHOM YOU WILL PICK UP YOUR GRADED MID-TERM EXAM: Rachel Bernstein Padma Gunda Katie Thoren James Fraser This exam consists of 4 questions, each worth 25 points total, as indicated below, for a total of 100 points. Question Part A Part B Part C Part D Your Total Maximum Score 1. (12) (13) -------------- --------------- 25 2. (10) (15) -------------- --------------- 25 3. (5) (4) (6) (10) 25 4. (9) (16) ------------- ------------- 25 TOTAL ---------- ---------- ---------- ----------- 100
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UC Berkeley, Chem C130/MCB 100A, Fall 2007, Mid-term Exam 1. Your Name___________________________ Page 2 of 15 Question 1 (25 points total) Q1A (12 points). Shown below are nine nucleotide bases. (i) (4 points). Circle the 4 bases that are found in DNA. (ii)(8 points) In the diagram below, draw the Watson-Crick basepair that is found in RNA but not in DNA. For each base, draw the complete chemical structure of the base and all the hydrogen bonds, and the connection to the ribose sugar (you need not draw the ribose structure in detail). Indicate the major groove and minor groove edges of the basepair.
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UC Berkeley, Chem C130/MCB 100A, Fall 2007, Mid-term Exam 1. Your Name___________________________ Page 3 of 15 Question 1, contined Q1B (13 points) Shown below are three double helical structures: ____-FORM _____-FORM _____-FORM (i) (3 points) Label these A form, B form and Z form. Explain briefly the reasons for each choice. (ii) (3 points) RNA cannot readily adopt the B-form double helical structure. Explain why this is the case.
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UC Berkeley, Chem C130/MCB 100A, Fall 2007, Mid-term Exam 1. Your Name___________________________ Page 4 of 15 Question 1B, continued. (iii) (4 points) The B-form double helical structure has an advantage over the A-form for transcriptional control. Explain briefly the nature of this advantage. (iv) (3 points) The Z-form double helical structure is rarely adopted in DNA, but it is found to occur just before the regions of double helical DNA that need to open up to form a bubble, such as before a gene to be transcribed. Explain why this might be the case.
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UC Berkeley, Chem C130/MCB 100A, Fall 2007, Mid-term Exam 1. Your Name___________________________ Page 5 of 15 Question 2. (25 points total)
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This note was uploaded on 02/23/2011 for the course MCB 100A taught by Professor Kuryian during the Spring '09 term at University of California, Berkeley.

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Midterm 1 Problems - 2007 - UC Berkeley, C hem C130/MC B...

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